منابع مشابه
Heterogeneity in White Blood Cells Has Potential to Confound DNA Methylation Measurements
Epigenetic studies are commonly conducted on DNA from tissue samples. However, tissues are ensembles of cells that may each have their own epigenetic profile, and therefore inter-individual cellular heterogeneity may compromise these studies. Here, we explore the potential for such confounding on DNA methylation measurement outcomes when using DNA from whole blood. DNA methylation was measured ...
متن کاملDNA methylation in paired breast epithelial and white blood cells from women undergoing reduction mammoplasty.
BACKGROUND The extent to which white blood cell (WBC) DNA methylation provides information on the status of breast epithelial cell DNA is unknown. PATIENTS AND METHODS We examined the correlation between methylation in Ras-association domain family-1 gene (RASSF1), a tumor-suppressor gene, and methylation in repetitive elements in paired sets of DNA from WBC and breast epithelial cells collec...
متن کاملRelationships between Global DNA Methylation in Circulating White Blood Cells and Breast Cancer Risk Factors
It is not yet clear whether white blood cell DNA global methylation is associated with breast cancer risk. In this review we examine the relationships between multiple breast cancer risk factors and three markers of global DNA methylation: LINE-1, 5-mdC, and Alu. A literature search was conducted using Pubmed up to April 1, 2016, using combinations of relevant outcomes such as "WBC methylation,...
متن کاملBulky DNA Adducts in White Blood Cells: A Pooled Analysis
Background: Bulky DNA adducts aremarkers of exposure to genotoxic aromatic compounds, which reflect the ability of an individual to metabolically activate carcinogens and to repair DNA damage. Polycyclic aromatic hydrocarbons (PAHs) represent a major class of carcinogens that are capable of forming such adducts. Factors that have been reported to be related to DNA adduct levels include smoking,...
متن کاملExposure to aflatoxin B1 in utero is associated with DNA methylation in white blood cells of infants in The Gambia.
BACKGROUND Exposure to environmental toxins during embryonic development may lead to epigenetic changes that influence disease risk in later life. Aflatoxin is a contaminant of staple foods in sub-Saharan Africa, is a known human liver carcinogen and has been associated with stunting in infants. METHODS We have measured aflatoxin exposure in 115 pregnant women in The Gambia and examined the D...
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ژورنال
عنوان ژورنال: Epigenetics
سال: 2011
ISSN: 1559-2294,1559-2308
DOI: 10.4161/epi.6.7.16500